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Painkillers, paracetamol

Paracetamol is a painkilling (analgesic) medicine available over-the-counter without prescription from a GP.

Paracetamol is a painkilling (analgesic) medicine available over-the-counter without a prescription.

Paracetamol can be used to:

  • ease mild to moderate pain  for example, headaches, sprains, or toothache
  • control a fever (high temperature, also known as pyrexia)  for example, when someone has the flu (influenza)

Types of paracetamol products

Paracetamol is available as:

  • tablets
  • caplets
  • capsules
  • soluble tablets (these dissolve in water, which you then drink)
  • an oral suspension (liquid medicine)
  • suppositories, which are inserted into your anus (the opening through which waste leaves your body)

Some types of paracetamol, such as liquid forms of paracetamol, are aimed specifically at children.

Paracetamol is sold by a range of manufacturers, under many different brand names. In some countries, paracetamol is known as acetaminophen.

Paracetamol with other medicines

In some products, paracetamol is combined with other ingredients. For example, it may be combined with a decongestant (a type of medicine that provides short-term relief for a blocked nose) and sold as a cold and flu remedy.

Paracetamol may also be combined with other painkillers in medicines, such as:

  • co-codamol (paracetamol and codeine)
  • co-dydramol (paracetamol and dihydrocodeine)
  • Tramacet (paracetamol and tramadol)

The packaging should state whether a product contains paracetamol or not, and how much. This will usually be in milligrams (mg). For example, one paracetamol tablet may contain 500mg of paracetamol.

How it works

Paracetamol works as a painkiller by affecting chemicals in the body called prostaglandins. Prostaglandins are substances released in response to illness or injury. Paracetamol blocks the production of prostaglandins, making the body less aware of the pain or injury.

Paracetamol reduces temperature by acting on the area of the brain responsible for controlling temperature.

Who can use paracetamol?

Paracetamol should be used with caution by those with liver problems, kidney problems, or alcohol dependence. Read more about special considerations for paracetamol.

Side effects are rare but can include a rash or swelling. Read more about side effects of paracetamol.

Paracetamol may interact with some other medicines, including some medicines taken to treat cancer or epilepsy. Read more about paracetamol interactions.

Use in children

Babies and children can be given paracetamol to treat fever or pain if they are over two months old. 

For example, one dose of paracetamol may be given to babies who are two or three months old if they have a high temperature following vaccinations. This dose may be repeated once after six hours.

High doses of paracetamol (500mg or more) are not licensed for children under 16 years old and should not be given to children under 12 years old.

Check the packet or patient information leaflet to make sure that the medicine is suitable for children and to find out the correct dose. When paracetamol is given to babies or children, the correct dose may depend on:

  • the child’s age
  • the child’s weight
  • the strength of the paracetamol – this is usually in milligrams (mg)

If your baby’s or child’s high temperature does not get better, or they are still in pain, speak to your GP or call NHS 111.

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Painkillers, paracetamol

Learn about the rare side effects of paracetamol, including a rash and blood disorders, and liver or kidney damage resulting from an overdose.

Side effects from paracetamol are rare.

However, side effects can include:

  • a rash or swelling – this could be a sign of an allergic reaction
  • hypotension (low blood pressure) when given in hospital by infusion (a continuous drip of medicine into a vein in your arm) 
  • liver and kidney damage, when taken at higher-than-recommended doses (overdose)

In extreme cases the liver damage that can result from a paracetamol overdose can be fatal.


Make sure you take paracetamol as directed on the label or as instructed by a health professional. Unless instructed otherwise, do not take more than four doses of paracetamol within 24 hours.

If you think you have taken too much paracetamol, go to your nearest accident and emergency (A&E) department.

Paracetamol can also be associated with blood disorders, such as thrombocytopenia (low platelet count) and leukopenia (low number of white blood cells), but this is extremely rare. 

Driving ability

Paracetamol, taken at recommended doses, is not known to interfere with your ability to drive.

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Painkillers, paracetamol

Always take paracetamol as directed on the packet or patient information leaflet that comes with the medicine, or as directed by your GP or pharmacist.

When taking paracetamol, follow the instructions of your doctor or pharmacist. If you've bought paracetamol over-the-counter, read the instructions on the packet or patient information leaflet that comes with the medicine.

Doses of paracetamol are usually taken every four to six hours.

Make sure you allow the recommended time between doses, and do not exceed the maximum dose for a 24-hour period.

Missed doses

If you forget to take your dose of paracetamol, check the patient information leaflet that comes with your medicine. You may be able to take the missed dose when you remember, or you may need to miss it out completely.

Don't take a double dose to make up for the missed dose – continue to leave four to six hours between doses.

Extra doses

If you accidentally take an extra dose of paracetamol, you should miss out the next dose so that you do not take more than the recommended maximum dose for a 24-hour period.

If you are concerned or you feel unwell, contact your GP or call NHS 111.

If you have taken more than the recommended maximum dose of paracetamol, go to accident and emergency (A&E) immediately. Taking too much paracetamol may result in liver damage. This can cause nausea (feeling sick) and vomiting (being sick) that lasts around 24 hours.

In extreme cases, taking too much paracetamol may lead to:

  • encephalopathy (problems with brain function)
  • haemorrhage (bleeding)
  • hypoglycaemia (low blood sugar)
  • cerebral oedema (fluid on the brain)
  • death

Further advice

If you need further advice about missed or extra doses of paracetamol you can:

  • contact your GP or pharmacist
  • call NHS 111

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