Content Supplied by NHS Choices

Anti-inflammatories, non-steroidal

Non-steroidal anti-inflammatory drugs (NSAIDs) work by interfering with particular enzymes in your body

Non-steroidal anti-inflammatory drugs (NSAIDs) work by interfering with particular enzymes in your body.

Enzymes are a special type of protein which help to bring about, or speed up, a chemical reaction within your body. For example, digestive enzymes help your digestive system break up large food particles into smaller pieces so your body can absorb them.

There are many enzyme systems in the body. One enzyme system involved in inflammation and pain is called the cyclo-oxygenase system.

Cyclo-oxygenase

NSAIDs interfere with an enzyme called cyclo-oxygenase (COX). Different parts of your body have different types of COX enzymes, which control the production of chemicals called prostaglandins. Different prostaglandins have different functions.

For example, the stomach contains a sub-type of COC called COX. This enzyme controls the production of substances called prostaglandins that help protect the stomach from acid (which is normally present in the stomach). Another sub-type called COX-2 enzymes are mainly activated during infection, injury or inflammation, and produce the prostaglandins involved in pain and inflammation.

NSAIDs can reduce pain and inflammation by preventing COX enzymes releasing the prostaglandin chemicals that cause pain and inflammation. However, prostaglandins carry out many different functions within your body. Interfering with them can cause a number of side effects, such as indigestion, inflammation of the stomach lining and stomach ulcers.

COX-2 inhibitors

To prevent side effects, researchers developed a new 'family' of NSAIDs known as COX-2 inhibitors.

These are designed to block the enzymes that cause pain and inflammation but avoid blocking the enzymes that protect the stomach lining. This helps reduce the risk of indigestion and stomach ulcers.

Although COX-2 inhibitors have less effect on the stomach, they might be more likely than traditional NSAIDs to cause side effects to the heart. Further research into this issue is ongoing. This means they may be more suitable for someone at risk of developing stomach or intestinal problems, but less suitable for those with a heart or circulation problem.


Pain
Pain is an unpleasant physical or emotional feeling that your body produces as a warning sign it has been damaged.
Swelling
Inflammation is the body's response to infection, irritation or injury, which causes redness, swelling, pain and sometimes a feeling of heat in the affected area.
Tissue
Body tissue is made up of groups of cells that perform a specific job, such as protecting the body against infection, producing movement or storing fat.
Content Supplied by NHS Choices

Anti-inflammatories, non-steroidal

There are a number of situations where the use of non-steroidal anti-inflammatory drugs (NSAIDs) is not recommended

There are a number of situations where the use of non-steroidal anti-inflammatory drugs (NSAIDs) is not recommended.

In some cases, they should only be used if you are directly instructed to by your GP or another qualified healthcare professional.

When to avoid NSAIDs

Children under 16 years old

Aspirin should never be given to children under 16 years of age because there is a small risk it could trigger a serious and potentially fatal condition called Reye’s syndrome. This condition can cause liver and brain damage. Paracetamol or ibuprofen are safer alternatives for children under 16.

Pregnant women

The use of NSAIDs during pregnancy is not recommended unless paracetamol does not effectively treat a particular condition. If an NSAID needs to be used, ibuprofen is the safest NSAID to use during pregnancy. If possible, it's best to avoid taking any medication during pregnancy for minor conditions.

However, it should be taken at the lowest possible dose to treat symptoms for the shortest possible time. NSAIDs, including ibuprofen, should never been taken from the 30th week of pregnancy onwards. This is because it can cause a dangerous rise in blood pressure (pulmonary hypertension) inside the lungs of the baby.

Breastfeeding women

The use of NSAIDs during breastfeeding is not recommended unless it is felt that the benefits of treatment outweigh the risks to your baby. If an NSAID is to be used, ibuprofen will be recommended at the lowest possible dose for the shortest possible time needed to treat your symptoms.

Asthma

Some people with asthma find that taking an NSAID can make their asthma symptoms more severe. If this happens to you, it is best to avoid taking NSAIDs in future (unless directly instructed to by your GP or other qualified health professional), and take paracetamol instead.

Allergic reaction

If you experience an allergic reaction after taking an NSAID (including aspirin), such as swelling of your eyes and lips (angioedema) or a severe skin rash, you should avoid taking NSAIDs in the future.

Cautions

Stomach ulcers

NSAIDs can increase your risk of developing stomach ulcers and experiencing internal bleeding, particularly if taken on a long-term basis. Therefore, if you have an increased risk of developing stomach ulcers and internal bleeding, you may wish to use an alternative medication – read more about alternatives to NSAIDs.

Things that increase your risk of developing stomach ulcers and internal bleeding include:

  • being 55 years of age or older
  • having a history of stomach ulcers or internal bleeding inside your digestive system
  • taking another medication known to increase the risk of stomach ulcers and internal bleeding

Medications known to increase the risk of stomach ulcers and internal bleeding include:

However, there are some health conditions for which long-term use of NSAIDs may be the only effective method of relieving symptoms. For example:

If you need to take NSAIDs on a long-term basis and have an increased risk of developing stomach ulcers and bleeding, you will probably be given an additional medication known as a proton pump inhibitor (PPI) or an an H-2 antagonist.

PPIs and H-2 antagonists help to prevent stomach ulcers and internal bleeding by reducing the production of stomach acid. See treating stomach ulcers for more information about PPIs and H-2 antagonists.

If you are taking an NSAID, avoid smoking and drinking large amounts of alcohol as these activities can increase your risk of developing stomach bleeding.

Cardiovascular and kidney conditions

In rare cases, NSAIDs can damage the kidneys and cardiovascular system (the heart and blood vessels).

The use of NSAIDs is not usually recommended for people who have an increased risk of developing cardiovascular or kidney conditions. Examples of these include:

Liver disease

If you have liver disease then NSAIDs may not be suitable for you.

Some types of liver disease include:

  • alcoholic liver disease – where the liver becomes damaged by alcohol misuse, which in severe cases, can result in cirrhosis (scarring of the liver)
  • hepatitis – inflammation of the liver which is often the result of a viral infection, but can also be non-viral
  • liver failure – where the liver loses most, or all, of its functioning capability


Content Supplied by NHS Choices

Anti-inflammatories, non-steroidal

You may not always be able to take non-steroidal anti-inflammatory drugs (NSAIDs) in combination with other medicines.

You may not always be able to take non-steroidal anti-inflammatory drugs (NSAIDs) in combination with other medicines. This is because some combinations of medicines can cause harmful side effects.

Taking NSAIDs can also make certain medicines less effective. This could be potentially dangerous if these other medicines are treating a serious condition, such as high blood pressure (hypertension).

Some commonly used medications known to interact with NSAIDs are outlined below.

(This is not a complete list; always carefully read the information leaflet that comes with your medication in case there are other interactions that apply to you).

Low-dose aspirin

Low-dose aspirin is given as a preventative treatment to thin the blood in people thought to be at risk of a blood clot which could then trigger a heart attack and stroke.

The use of NSAIDs are not usually recommended for people taking low-dose aspirin because:

  • NSAIDs can make the aspirin less effective in thinning the blood
  • the combination of the two medications can increase the risk of stomach ulcers forming

If the use of an NSAID is thought to be absolutely necessary then you may be switched to an alternative blood thinning medication such as clopidogrel. This will require an H-2 antagonist to also be prescribed as PPIs cannot be used with clopdorel.

Ciclosporin

Ciclosporin is a medication used to treat autoimmune conditions such as arthritis or ulcerative colitis.

It is also used in people who have received an organ transplant to prevent their body rejecting the transplant.

There is a small risk of experiencing kidney and liver damage if you take NSAIDs while also taking ciclosporin.

So if you need to take both medications at the same time you may be referred for regular blood tests so the state of your liver and kidneys can be assessed.

Diuretics

Diuretics are a group of medications that help remove fluid from the body and are often used in the treatment of high blood pressure.

Diuretics are generally safe to take in combination with NSAIDs but you will need to be monitored as they can occasionally cause kidney damage and also lead to a rise in blood pressure.

Lithium

Lithium is a type of medication used to treat bipolar disorder and severe depression.

Taking NSAIDs in combination with lithium can disrupt the body’s ability to remove lithium from the body which can lead to a dangerous build-up of lithium levels.

If using NSAIDs is thought to be absolutely necessary, your dosage of lithium may need to be reduced and you will need regular blood tests to check lithium levels.

You should be alert for the symptoms of lithium poisoning, which include:

  • ataxia (loss of balance and co-ordination)
  • blurred vision
  • dizziness 
  • muscle twitching
  • tinnitus (ringing in your ears)

Methotrexate

Methotrexate is a medication used to treat rheumatoid arthritis. Seek advice from a doctor before taking methotrexate alongside NSAIDs.

Phenytoin

Phenytoin is a medication used to treat epilepsy. Seek advice from a doctor before taking phenytoin alongside NSAIDs.

Selective serotonin reuptake inhibitors

Selective serotonin reuptake inhibitors (SSRIs) are a group of medications used to treat depression as well as a number of other mental health conditions, such as anxiety disorder and obsessive compulsive disorder.

There is evidence that taking SSRIs in combination with an NSAID can increase the risk of a person experiencing bleeding inside their digestive system. It's likely that long-term use will also require a PPI or H-2 antagonist to be prescribed to reduce this risk.

The risk is thought to be small, but as a precaution you should be alert for signs that bleeding has taken place.

Depending on the location and type of blood vessel, you may have long-term bleeding which could lead to anaemia. Symptoms of anaemia include:

Alternatively, the bleeding can be rapid and massive, causing you to vomit blood or pass stools that are black and tar-like.

Warfarin

Warfarin is a medication used to treat people with a history of blood clots, or those thought to have a high risk of developing blood clots at a later date.

The use of NSAIDs is not usually recommended for people taking warfarin as it can enhance the effects of the medication and make you prone to excessive bleeding. In rare cases, a specialist may prescribe this combination.

Alcohol

It is usually safe to drink alcohol while taking an NSAID, as long as you stick to the recommended daily limits (three to four units of alcohol a day for men, and two to three units for women).

Drinking more than the recommended daily limit of alcohol may irritate your stomach lining. Therefore, you may be unable to take NSAIDs if you are going to drink more than the recommended daily limit.

If you are a heavy drinker and you take an NSAID, the risk of you having bleeding in your stomach may be higher. Speak to your GP or pharmacist if you are not sure whether you should be taking NSAIDs.

Food

There are no known interactions between NSAIDs and food. Ideally, take NSAIDs after eating and avoid taking them on an empty stomach. This will help minimise the risk of the medicine upsetting your stomach.

Other NSAIDs

It is always best to use one type of NSAID at a time to minimise the risks of side effects. If you have been prescribed a prescription-only NSAID, such as celecoxib, avoid taking any over-the-counter medication that contains ibuprofen or aspirin.

Many cold and flu remedies contain a combination of different medications, one of which is often an NSAID, such as ibuprofen.

So always carefully read the packet to check for possible interactions. Taking these sorts of remedies after already taking an NSAID could be potentially dangerous.



Content Supplied by NHS Choices

Anti-inflammatories, non-steroidal

Before prescribing a non-steroidal anti-inflammatory drug (NSAID), your GP will consider whether there is an alternative form of treatment.

Before prescribing a non-steroidal anti-inflammatory drug (NSAID), your GP will consider whether there is an alternative form of treatment that may be suitable. This will minimise your risk of having any side effects.

If your GP feels NSAIDs are the most appropriate form of treatment, they will prescribe the lowest effective dose for the shortest period of time necessary.

It is better to prescribe a low dose over a short period of time and, if necessary, to gradually increase it. By doing this, any side effects should not be as severe.

Effects of specific NSAIDs

Your tolerance to different types of NSAIDs can vary greatly, as can your pain relief. While one type of NSAID may cause no side effects and be very effective, another type may not be as effective, or it may have an adverse effect on your gastrointestinal tract, heart, circulation or kidneys.

Therefore, before prescribing a different type of NSAID, your GP will carefully consider your individual circumstances and your likelihood of having any sort of reaction to the medicine. Do not switch between NSAIDs unless your GP agrees that it is safe for you to do so.

Overdose

It is important to strictly follow all instructions about the recommended dosage for your particular NSAID. If you exceed the recommended dose, you risk experiencing adverse effects, which could be minor, moderate, or serious.

Minor effects of an overdose include:

  • upset stomach
  • skin irritation
  • drowsiness
  • tachycardia (rapid heartbeat)

Moderate effects of an overdose include brief seizures (fits), particularly with an NSAID called mefenamic acid.

If you think you or someone else is having mild or moderate effects of an NSAID overdose, contact your GP immediately for advice. If this is not possible, call NHS 111.

Serious effects of an overdose include:

  • prolonged and repeated seizures (fits)
  • serious breathing difficulties
  • loss of consciousness

A serious NSAID overdose is a medical emergency. If you think you or someone else is having serious effects of an NSAID overdose, call 999 immediately and ask for an ambulance.


Dose
Dose is a measured quantity of a medicine to be taken at any one time, such as a specified amount of medication.
Inflammation
Inflammation is the body's response to infection, irritation or injury, which causes redness, swelling, pain and sometimes a feeling of heat in the affected area.

Share this page