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Hepatitis C

Only around one in four people have symptoms during the first six months of a hepatitis C infection. This stage is known as acute hepatitis C.

Only around one in four people will have symptoms during the first six months of a hepatitis C infection. This stage is known as acute hepatitis C.

The symptoms may include:

  • a high temperature of 38oC (100.4oF) or above
  • tiredness
  • loss of appetite
  • stomach pains
  • feeling sick
  • being sick

These symptoms occur a few weeks after infection.

In people who do have symptoms of acute hepatitis C, around one in five of them will also experience yellowing of the eyes and skin. This is known as jaundice.

In an estimated one in five cases of hepatitis C, the immune system will successfully eliminate the virus and the person will have no further symptoms (unless they become infected again).

In the remaining cases, the virus persists inside the body for many years. This is known as chronic hepatitis.

Chronic hepatitis C

The symptoms of hepatitis C can vary widely from case to case. In some people, symptoms may be barely noticeable. In others, they can have a significant impact on quality of life.

The symptoms can also go away for long periods of time (remission) and then return.

Some of the most commonly reported symptoms of hepatitis C include:

  • feeling tired all the time – sleeping does not seem to help improve energy levels
  • headaches
  • depression 
  • problems with short-term memory, concentration and completing relatively complex mental tasks such as mental arithmetic – many people describe this combination of symptoms as "having a brain fog"
  • mood swings
  • indigestion or bloating
  • joint and muscle aches and pain
  • itchy skin 
  • flu-like symptoms, like those that occur in the acute phase of the infection
  • abdominal pain
  • pain in the liver area (which is located in the right upper side of your abdomen)

When to seek medical advice

See your GP if you persistently have any of the chronic symptoms above, or if they keep returning, especially if you inject drugs or have injected drugs in the past.

None of the symptoms above automatically means you have hepatitis C, but they do require further investigation.

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Hepatitis C

You can become infected with hepatitis C if you come into contact with the blood or, less commonly, the body fluids of an infected person.

You can become infected with hepatitis C if you come into contact with the blood of an infected person.

The blood has the highest concentration of the virus, so exposure to infected blood is the easiest way to get the virus. Just a small trace of blood can cause an infection.

The virus can survive outside the body in patches of dried blood on surfaces for at least 16 hours, but no longer than four days (at room temperature conditions).

Injecting drugs

Injecting drugs is the most important risk factor for hepatitis C in the UK. Up to 49% of people who inject drugs in England are thought to have hepatitis C.

The infection can be spread by sharing needles and associated equipment. Injecting yourself with just one contaminated needle may be enough to become infected.


There have also been reports of people catching hepatitis C when sharing bank notes or straws to snort cocaine.

Cocaine can damage the inside of the nose, leading to bleeding. It's possible to then inhale contaminated blood and become infected.

Less common causes

Unprotected sex

Hepatitis C may be transmitted during unprotected sex (sex without using a condom), although this risk is considered very low.

The risk of transmission through sex may be higher among men who have sex with men. The risk is also increased if there are genital sores or ulcers from a sexually transmitted infection, or if either person also has HIV.

The best way to prevent transmission of hepatitis C through sex is to use a male condom or female condom.

However, as the risk is very low for couples in a long-term, stable relationship, many choose not to use a condom. If your partner has hepatitis C, you should be tested for the condition.

Blood donations before September 1991

Since September 1991, all blood donated in the UK is checked for the hepatitis C virus. If you received blood transfusions or blood products before this date, there is a possibility you were infected with hepatitis C.

Blood transfusions and treatment abroad 

If you have a blood transfusion or medical or dental treatment overseas where medical equipment is not sterilised properly, you may become infected with hepatitis C. The virus can survive in traces of blood left on equipment.

Sharing toothbrushes, scissors and razors

There is a potential risk that hepatitis C may be passed on through sharing items such as toothbrushes, razors and scissors.

Equipment used by hairdressers can pose a risk if it has been contaminated with infected blood and not been sterilised or cleaned between customers. However, most salons operate to high standards, so this risk is low.

Tattooing and body piercing

There is a potential risk that hepatitis C may be passed on through using tattooing or body piercing equipment that has not been properly sterilised.

However, most tattoo and body piercing parlours in the UK operate to high standards and are regulated by law, so this risk is low.

Mother to child

There is a small chance that a mother who is infected with the hepatitis C virus will pass the infection on to her baby. This can happen in around 2% of cases.

However, the risk is thought to increase if the mother also has HIV or particularly high levels of the virus.

Needlestick injury

There is a small (approximately one in 30) risk of getting hepatitis C if your skin is accidentally punctured by a needle used by someone with hepatitis C.

Healthcare workers, nurses and laboratory technicians are at increased risk because they are in regular close contact with blood and bodily fluids that may contain blood.

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Hepatitis C

Most cases of acute hepatitis C are not treated as the person either does not have any symptoms or mistakes the symptoms for the flu.

Most cases of acute hepatitis C are not treated as the person either does not have any symptoms or mistakes the symptoms for the flu.

If hepatitis C is detected during this acute phase, it is normally recommended that you are monitored for three months to see if your body fights off the virus.

If it doesn’t, a six-month course of pegylated interferon (see below) may be recommended. This is successful at curing the infection in around 85% of cases.

Chronic hepatitis C

Treatment for chronic hepatitis C usually involves using a combination of two medicines:

  • pegylated interferon (given as an injection) – a synthetic version of a naturally occurring protein in the body that stimulates the immune system to attack virus cells
  • ribavirin (given as a capsule or tablet) – an antiviral drug that stops hepatitis C from spreading inside the body

This is known as combination therapy.

Course and dosage

The length of your recommended course will depend on which genotype of the hepatitis C virus you have.

If you have genotype 1, a 48-week course is recommended. For all other genotypes, a course of 24 weeks will be recommended.

You may have a blood test four weeks into your course, and again at 12 weeks. If the test shows that the medications are having little effect in removing the virus, it may be recommended that treatment is stopped as further treatment may be of little use.

You are normally given weekly injections of pegylated interferon. Ribavirin is normally taken twice a day with food.

How effective is treatment?

The effectiveness of combination therapy depends on the genotype of the hepatitis C virus.

Genotype 1 is more challenging to treat. Only half of people treated with combination therapy will be cured.

Other genotypes respond better to treatment, with a cure rate of around 75–80%.

Side effects

Side effects of combination therapy are common and can be severe. Three out of four people being treated will experience one or more side effect.

Side effects of combination therapy include:

  • a drop in the number of red blood cells (anaemia), which can make you feel tired and out of breath
  • loss of appetite
  • depression
  • anxiety
  • irritability
  • problems sleeping (insomnia)
  • difficulties concentrating and remembering things
  • hair loss
  • itchiness
  • feeling sick
  • dizziness
  • flu-like symptoms, such as a high temperature, that occur in the 48 hours after an interferon injection

Side effects may improve with time as your body gets used to the medications.

Tell your care team if any side effect is becoming particularly troublesome as your dosage may need to be adjusted.

Coping with side effects may be challenging, but it is recommended that you continue to take medication as instructed.

Missing doses to try to minimise side effects will reduce the chances of you being cured.

Ribavirin and pregnancy

Ribavirin will harm an unborn child if it is taken by a pregnant woman. If you are a woman of childbearing age, you will need to have a pregnancy test to confirm you are not pregnant before treatment can begin. If you find out you are pregnant, treatment will need to be delayed until you have your baby.

If you are not pregnant, you will still need to use a reliable method of contraception (preferably two methods) if you are sexually active.

Men who are taking ribavirin should not have sex with a pregnant woman unless they use a condom. If their partner is not pregnant but is of childbearing age, she will need to be tested for pregnancy each month during treatment and for seven months after treatment has stopped.

Boceprevir and telaprevir

In April 2012, the National Institute for Health and Care Excellent (NICE) released guidance for two newer medications, boceprevir and telaprevir.

Both medications are known as protease inhibitors. Protease inhibitors block the effects of enzymes that viral cells need to reproduce.

The NICE guidance recommends that boceprevir or telaprevir should be made available free of charge on the NHS for people who:

  • have genotype 1 hepatitis C that has not previously been treated (a genotype is a particular viral strain)
  • have been treated for genotype 1 hepatitis C but treatment was unsuccessful

The medications are designed to be used in combination with pegylated interferon and ribavirin and not as a sole treatment. The tablet is taken three times a day for 48 weeks.

It is still unclear whether boceprevir or telaprevir is more effective.

Side effects of boceprevir include:

  • flu-like symptoms such as a high temperature and chills
  • loss of appetite
  • feeling sick
  • insomnia
  • weight loss
  • shortness of breath

Side effects of telaprevir include:

Deciding against treatment

Some people with chronic hepatitis C decide against treatment. There can be several reasons for this, for example if they:

  • do not have any symptoms
  • are willing to live with the risk of cirrhosis at a later date
  • do not feel the potential benefits of treatment outweigh the side effects treatment can cause

Your care team can give you advice about this, but the final decision about treatment will be yours.

If you decide not to have treatment but then change your mind, you can still request to be treated.


If the virus is cleared with treatment, you are not immune to future infections of hepatitis C.

This means, for example, that if you continue to inject drugs after taking the medicines, you risk becoming re-infected with hepatitis C.


It is possible to be infected with more than one type of hepatitis, which can complicate treatment.

Therefore, if you have chronic hepatitis C, your GP or practice nurse may recommend that you are vaccinated against hepatitis A and hepatitis B.

They may also recommend that you consider vaccination against seasonal flu and pneumococcal infections.

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Hepatitis C

If it is not treated, chronic hepatitis C can sometimes cause scarring of the liver (cirrhosis). This can develop up to 20 years after you first become infected.

If it is not treated, chronic hepatitis C can sometimes cause scarring of the liver (cirrhosis). This can develop up to 20 years after you first become infected.

A number of factors can increase your risk of getting cirrhosis, such as:

Depending on these factors, the risk of cirrhosis can range from 10% to 40%.

Symptoms of cirrhosis include:

  • tiredness and weakness
  • loss of appetite
  • weight loss
  • feeling sick
  • very itchy skin
  • tenderness or pain around the liver
  • tiny red lines (blood capillaries) on the skin above waist level
  • jaundice 

Other than a liver transplant, there is no cure for cirrhosis. However, treatments can help relieve some of the symptoms of cirrhosis and prevent the condition from worsening.

Read more about the treatment of cirrhosis.

Liver failure

In severe cases of cirrhosis, the liver loses most or all of its functions. The liver has a wide range of functions, such as filtering toxins from the blood and producing a number of important hormones.

This is known as liver failure or end stage liver disease. Liver failure occurs in around one in five people with hepatitis-associated cirrhosis.

Symptoms of liver failure include:

  • hair loss
  • build-up of fluid in the legs, ankles and feet (oedema)
  • build-up of fluid in your abdomen that can make you look heavily pregnant (ascites)
  • dark urine
  • black, tarry stools or very pale stools
  • frequent nosebleeds and bleeding gums
  • a tendency to bruise easily
  • vomiting blood

Once liver failure has occurred, it is usually possible to sustain life for several years using medication. However, a liver transplant is currently the only way to cure liver failure.

Liver cancer

It is estimated that around one in 20 people with hepatitis-associated cirrhosis will develop liver cancer.

Symptoms of liver cancer include:

  • unexplained weight loss
  • feeling sick
  • vomiting
  • tiredness
  • jaundice

It is usually not possible to cure liver cancer, especially in people with cirrhosis, though chemotherapy can be used to slow the spread of the cancer.

Read more about the treatment of liver cancer.

Other complications

Other rarer complications of chronic hepatitis C include:

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Hepatitis C

Answers to questions about living with hepatitis C, including questions about diet, the workplace, travelling and having a baby.

Below are answers to some questions about living with hepatitis C, including questions about diet, the workplace, travelling and having a baby.

If you have hepatitis C, the following questions are answered below:

Do I need to eat a special diet?

You will not usually need to change what you eat, as long as you eat a healthy, varied diet.

If your liver is badly damaged, however, your doctor may suggest limiting your intake of salt and protein to avoid putting too much strain on your liver. The hospital dietitian can advise you on what you can and cannot eat.  

Could anything I do make hepatitis C worse?

Drinking alcohol can increase the damage to your liver. If you have hepatitis C, cut out or limit your intake of alcohol. If you need advice about this, ask your doctor or contact an alcohol self-help organisation.

Read more about tips on cutting down your alcohol consumption.

If you are concerned that you are addicted to alcohol and are unable to stop drinking, contact your GP. Medications are available to help people quit alcohol.

Read more about treating alcohol misuse.

Is there anything else I can do to help myself?

Control your weight by eating a healthy diet and exercising regularly (aim for 150 minutes a week).

Some studies suggest that being overweight raises the risk of fatty deposits in the liver, which could make your condition worse. Being a healthy weight can also help you respond better to treatment.

Read more about healthy eating and fitness.

Do I have to tell my boss?

You do not have to tell your boss that you have hepatitis C, unless you are a healthcare worker.

However, if hepatitis C is affecting your performance at work and your employer knows about your condition, they may be obliged to make allowances for you, such as giving you leave of absence for going to the clinic, under the Equality Act 2010. Therefore, you may want to consider telling your boss about your condition. You may also be entitled to statutory sick pay to cover doctor appointments or time off work.

Can I travel abroad?

If you are planning to travel abroad, seek advice from your doctor or a travel clinic about vaccination.

It is also a good idea to take any documentation, such as details of blood tests or medical records, in case you need medical treatment abroad.

Read more about travel vaccinations and accessing healthcare abroad.

Can I have a baby if I or my partner has hepatitis C?

Yes, but there is a small risk (around 2%) of hepatitis C passing from mother to baby. The risk is higher if the mother also has HIV. If the male partner has hepatitis C, there is a very small risk the virus could spread to the female during sex. If you are female with a male partner who has hepatitis C, you may want to have a hepatitis C test.

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Hepatitis C

We asked Dr Janice Main, a consultant in infectious diseases at St Mary’s Hospital, London, what she would want to know if she had hepatitis C.What symptoms

We asked Dr Janice Main, a consultant in infectious diseases at St Mary’s Hospital, London, what she would want to know if she had hepatitis C.

What symptoms can I expect?

If you catch hepatitis C, you might not notice. If you develop symptoms, you may feel slightly unwell and be off your food about six to eight weeks after being infected.

It would be unusual to get any more of the severe symptoms that some other types of hepatitis cause, such as jaundice.

How serious is it?

Between 20% and 40% of people who catch hepatitis C experience have no further problems.

However, in 60 to 80% of cases, infection becomes chronic (long-term). If left untreated, the infection can cause progressive liver damage.

Liver damage can lead to cirrhosis (a condition in which the liver becomes scarred), liver failure and liver cancer.

How can I prevent spreading it?

Hepatitis C is a bloodborne infection, so be careful about sharing razors or toothbrushes. Always cover any cuts to the skin.

If you are an injecting drug user, use clean needles and do not share ‘works’ (drug equipment). Dispose carefully of used needles and keep them away from children.

Always use condoms if you have sex.

If you are planning to conceive or you are pregnant, talk to the doctor at the antenatal clinic. They can arrange special blood tests for you and your baby.

Is there any treatment?

Yes. Drugs to treat hepatitis C are improving all the time, and there are now effective treatments.

Treatment is especially effective if it is given as soon as someone contracts hepatitis C (at the acute phase). However, the treatment can still be effective even if hepatitis C has become established.

The doctor will assess your general medical and mental health before offering treatment, as the treatment course can have significant side effects.

How will I be looked after?

You should be referred to a specialist hepatologist (liver specialist), gastroenterologist (specialist of the stomach and intestines) or infectious diseases specialist, who can monitor your condition.

You can expect to see them two or three times initially for blood tests, ultrasound and possibly a liver biopsy.

After that, you will usually see them every six to 12 months.

If you're offered medication, you will be seen more frequently to monitor whether the treatment is working, and how it is affecting you.

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